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In case of neurologic symptoms or abnormalities, it is suggested to administer hydroxocobalamin, 1000 mg once or twice weekly for a period of up to 2 years, and the package insert for hydroxocobalamin has included these particular instructions for several decades

Do not blow on it, do not wipe it, do not rush it

Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: Relationship between homocysteine levels and hyperinsulinemia

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