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Both drugs remain unaffordable for most patients without insurance or manufacturer savings programs

Third, the proportion of researchers achieving 20% or greater weight loss increases substantially from 5mg (32%) to 10mg (55%) but then shows diminishing returns at 15mg (63%)

[39] {Jrgensen, S.W., Hjort, L., Gillberg, L., Justesen, L., Madsbad, S., Brns, C., Vaag, A.A

Weight loss may also be associated with transient changes in thyroid hormone levels, particularly reduced T3 (triiodothyronine), though this typically represents a temporary adaptation to caloric restriction rather than medication-induced thyroid dysfunction