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When combined with gabapentin, this risk may increase, especially in higher doses or in people with respiratory conditions

Combination Therapies: Future clinical trials should explore whether combining GLP-1 agonists with other medications (eg, SGLT2 inhibitors or metformin) can enhance efficacy while reducing side effects

Use: In combination with a reduced calorie diet and increased physical activity, for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) Usual Pediatric Dose for Weight Loss 12 YEARS AND OLDER: Wegovy Injection: Initial dose (weeks 1 through 4): 0.25 mg subcutaneously once a week Dose escalation: Weeks 5 through 8: 0.5 mg subcutaneously once a week Weeks 9 through 12: 1 mg subcutaneously once a week Weeks 13 through 16: 1.7 mg subcutaneously once a week Alternatively: 1.7 mg subcutaneously once a week Comments: The recommended maintenance dose is 2.4 mg

Shedding excess weight can also reduce the risk of heart disease, high blood pressure, and high cholesterol