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The cells were treated with BAs (100 M, 24 h), including CDCA, TMCA, HDCA (T2968, TargetMol) and UDCA (T0700, TargetMol), for GLP-1 measurement and RNA isolation

In particular, the SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus) clinical trial evidenced neutral effects of saxagliptin in terms of cardiovascular outcomes, but an increased risk of hospitalization for HF, especially in patients with high levels of natriuretic peptides, previous HF, or chronic kidney disease [148]

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In the ACHIEVE-3 head-to-head trial, Foundayo outperformed oral semaglutide across the primary and key secondary endpoints