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Known functional roles of these nitrergic co-transmitters in learning, sleep, addiction, and other neurological disorders will be discussed to elucidate the adaptive value of nitrergic co-transmission, with a particular focus on nitrergic modulation of coincidence detection at NMDA receptors

Specific digestive enzymes, most notably gamma-glutamyltransferase (GGT) and various intestinal peptidases, cleave the tripeptide into its constituent amino acids long before it can reach systemic circulation intact

It plays a vital role in brain function, the production of DNA and, also, the production of red blood cells and nerve cells

While prohibitin is found in mitochondria in most cells, it acts as a receptor on the surface of adipose vasculature, providing a highly specific target for the peptide