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Common side effects include: Injection site reactions pain, redness, or swelling at the injection site Mild diarrhoea or gastrointestinal upset usually transient Skin reactions itching or rash (uncommon) Hypokalaemia rare, occurring when severe megaloblastic anaemia is corrected rapidly Serious adverse effects are extremely rare but may include anaphylaxis in hypersensitive individuals

Tirzepatide's dual GIP and GLP-1 receptor activation typically produces stronger appetite suppression than semaglutide's GLP-1-only mechanism

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Its the most stable form, because the cyanide molecule has the greatest attraction to the cobalamin, thus protecting it from conditions like high temperatures