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J Basic Microbiol 45(2):125135 Acknowledgements This work was supported by the National Science Centre, Poland Miniatura (no

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This process uses the GGT1 enzyme.[ref][ref] Enzyme reactions involving glutathione: Glutathione peroxidase (GPX1 gene, below) is an important enzyme that utilizes glutathione in antioxidant reactions, such as in neutralizing hydrogen peroxide and lipid peroxide

Tubular epithelial fibroblast transdifferentiation (TEMT) has been proposed as a viable therapeutic option to decrease RF since it stimulates the expression of several fibro-cytokines, which represent a critical mechanism in the development of RF ( SalB mitigates TEMT and has renal protective effects by down-regulating the expression of FGF2/TGF-1/-SMA via the HPSE/Syndecan-l axis ( 2.4.3 PDGF PDGF is a profibrotic mediator that induces fibroblast activation and proliferation and promotes ECM contraction ( SalB in reducing renal inflammation and CTGF production, improving renal function, and inhibiting the progression of RF through the PDGF-C/PDGFR pathway has been well-documented (Yao et al., 2022)