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the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

This suppression of breathing can lead to oxygen deprivation, unconsciousness, and in severe cases, death

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Zero adverse events Despite the invasive nature of the procedure (1,890 needle perforations per second at 2 mm depth), no adverse reactions were reported