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The MTHFR 1298AC mutation is also present in about 25% of the global population, occurring most frequently in those of South East Asian descent (42%) and Europeans (31%)

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It is known that excess lipid accumulation in non-adipose tissues is associated with higher concentrations of NEFA and TAG in the circulation, and that this is often accompanied by inflammation, oxidative stress and cellular dysfunction or death ( Reference Mattern and Hardin 53 Reference Perez-Martinez, Perez-Jimenez and Lopez-Miranda 55 )

The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota