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Semaglutide is also sold under two other brand names with different indications: Wegovy: semaglutide 0.25mg to 7.2mg, FDA-approved for chronic weight management, cardiovascular risk reduction, and adolescent obesity

Semaglutide is a well-known prescription medication used for weight loss and managing type 2 diabetes

Consistent with these findings, whole-mount analysis of the adult mouse intestine shows Esm1 immunostaining in the peri-arterial domain of the villus capillary network, which is characterized by pronounced anti-Caveolin 1 signal and absent Endomucin expression (Supplementary Fig

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