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In the SUMMIT trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

What drugmakers are arguing about now is what kind of weight comes off, whether patients are losing fat or muscle, and what other benefits could be gained from these drugs

While you may be tempted to turn to berberine as a fast fix for your weight loss woes, its important to note that evidence in favor of its weight loss effect is currently limited