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Common Side Effects The most frequent side effects for both forms include: Nausea/vomiting Usually mild and decreases over time Diarrhea Often temporary as your body adjusts Decreased appetite This is partly how the medication works Stomach upset Can be managed with dietary changes Stomach pain Typically a mild discomfort, but can be sharp Nausea tends to be more common with higher doses and often improves after the first few weeks of treatment

Eli Lilly released Phase 3 data for retatrutide on Thursday, and the obesity medicine world spent most of the day focused on one number: 45% of patients on the 12 mg dose lost more than 30% of their body weight