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Li, and A.N

Eles tambm ativaram neurnios na amgdala central , regio ligada ao desejo, e reduziram a liberao de dopamina em reas do circuito de recompensa

however, their effects are often modest and short-lived, with hypotension limiting sustained clinical use.32 Anti-inflammatory and NF-B targeted therapies can attenuate cytokine-mediated injury.33,34,40 Calcium channel blockers reduce intracellular calcium overload and cellular injury but demonstrate variable clinical efficacy and limited impact on inflammatory and oxidative pathways.41 Similarly, statins, dexmedetomidine, and antioxidant therapiesincluding N-acetylcysteine, allopurinol, and hydrogen-rich saline target reactive oxygen species and have shown protective effects in preclinical models