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The following mild side effects are frequently reported: Injection site irritation (temporary) Headaches Flushed skin or warm skin Mild water retention or bloating Sleepiness or vivid dreams Unlike older GH-Releasing peptides, Ipamorelin does not raise cortisol or prolactin levels to a significant extent, making it one of the more gentle options available

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Because these drugs are relatively new, we also do not know how long the weight stays off and how long people should be on the medication