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KD is an efficient treatment for pediatric drug-resistant epilepsy (DRE)

Neuroprotection in the Central Nervous System Glutathione (GSH) plays a vital neuroprotective role in the central nervous system (CNS), primarily by regulating redox homeostasis, detoxifying electrophilic compounds, and modulating excitotoxic signaling pathways

Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, Itsiopoulos C, Niyonsenga T, Blunden S, Meyer B, Segal L

Figure 3 Having demonstrated that metformin treatment alone induces cell death in both HCT116 and SW837 cells, the impact of metformin combined with a clinically-relevant dose of 1.8 Gy radiation was assessed at 48 h post radiation exposure