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Schroeder EK, Keley NA, et al

Subsequent RCTs in severe asthmatics showed that tezepelumab treatment resulted in a 4471% reduction in AAER, irrespective of baseline peripheral eosinophilia (Table 6) (Marone et al., 2019

Hydroxyethyl starch inhibits glycocalyx-degrading enzymes, facilitating the restoration of glycocalyx thickness and enhancing expression of VE-cadherin, occludin, and zonula occludens-1, reducing albuminfluorescein isothiocyanate infiltration, and improving pulmonary vascular permeability [45]

The classic human studies used 2530 nmol/kg intravenously approximately 1,485 mcg for a 70 kg adult at 25 nmol/kg administered in sleep laboratories