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However, CuCl 2 and Cu(OAc) 2 significantly upregulated the extracellular protein expression of the three genes at concentrations (58 M and 580 M) without inhibiting the cell viability after 24 h

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Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, DellItalia LJ, Dillmann WH, Litwin SE, Abel ED (2020) Maintaining myocardial glucose utilization in diabetic cardiomyopathy accelerates mitochondrial dysfunction

The elongation was sufficient to extend cellular proliferative capacity beyond the Hayflick limit the replicative ceiling normally imposed by critical telomere shortening