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also suggested an increased risk of cholangiocarcinoma associated with the use of DPP-4 inhibitors and GLP-1 RAs, but the study involving GLP-1 RAs had a wide confidence interval, leading to some uncertainty in the conclusion ( Regarding the possible mechanisms of biliary diseases caused by these two types of drugs, existing studies have proposed multiple hypotheses

The small size of these studies, however, means they are not conclusive