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Conclusion The meta-analysis confirms the HR increase but seems to exclude an alteration of the sympatho-vagal balance due to chronic treatment with GLP-1R agonists in diabetes, considering the available measures of ANS function

Because stopping semaglutide typically leads to some degree of weight regain , many people continue treatment to maintain their results and protect against weight-related health risks

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Oda N., Miyahara N., Taniguchi A., Morichika D., Senoo S., Fujii U., Itano J., Gion Y., Kiura K., Kanehiro A., et al

Its appetite-suppressing effects stem from multiple proposed physiological mechanisms that target both central and peripheral pathways involved in hunger regulation