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Phentermine, an FDA-approved appetite suppressant since 1959, works through central nervous system stimulation, while tirzepatide (Zepbound, Mounjaro), approved in 2023 for obesity, operates through dual GIP/GLP-1 receptor pathways

Results showed that Humanin mRNA expression was significantly elevated in the skeletal muscle of obese patients compared to healthy individuals, while no difference was observed in type 2 diabetes patients relative to controls

Some patients report mild diarrhoea, nausea, or headache following administration, though these symptoms are usually transient

Anti-inflammatory activity of superoxide dismutases studies on adjuvant induced polyarthritis in rats