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How Tirzepatide Works Tirzepatide works by tapping into two key gut hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

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10.1016/j.metabol.2013.09.009 Metabolism Summary Keywords T2DM (type 2 diabetes), GLP-1, -cell, PARP-1, ABCA1 Citation Li R, Sun X, Li P, Li W, Zhao L, Zhu L and Zhu S (2021) GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic -Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux

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