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This albumin-engineering strategy was also effective when applied with a therapeutic fusion partner, glucagon-like peptide 1 (GLP-1), resulting in a 2-fold increase in plasma half-life and prolonged efficacy in human FcRn transgenic mice

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Nonetheless, there was still a significant weak positive correlation across all mutant datasets and similar to exendin-4, mutations affecting both peptides generally had a greater effect on GLP-1 than oxyntomodulin signalling (Figures 4-5)