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Zofran blocks the downstream nausea signal

As high LRRK2 levels are observed in the inflamed colon in CD patients and in peripheral immune cells in sporadic PD patients, high levels and/or activities of LRRK2 may aggravate inflammatory processes in both CD and PD 17,18

CagriSema produces higher rates of nausea (55% versus 31%) and vomiting (26% versus 12%) compared to tirzepatide in their respective clinical trials

Looking ahead to 2026 and beyond, my hope is simple but demanding: that more patients truly benefit, access expands across markets, inequalities are reduced, and we can honestly say we gave patients the very best we could