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Another case is that patients with systemic sclerosis exhibit a higher ratio of X chromosome inactivation and decreased regulatory T cell activity (42)

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It is even more ironic that NF-B, a key molecule that serves as a double insurance for inflammatory response and cell survival in healthy tissues, still deviates from its original purpose, i.e., curbing tumor progression, in the advanced stage of cancer, and promotes tumor invasion, metastasis and immune escape [34]

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