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In clinical studies, it has been administered in doses between 0.5mcg/kg and roughly 16,000mcg/kg for up to 2 weeks [42, 43]

Advantages: Localized delivery to target tissue (skin, scalp) Non-invasive Lower systemic exposure Well-tolerated with established safety record in cosmeceuticals Limitations: Limited dermal penetration (molecular weight ~340 Da near the cutoff for transdermal absorption) No systemic anti-aging or anti-inflammatory effects Efficacy dependent on formulation vehicle (liposomal carriers significantly improve penetration) GHK-Cu Injection (Subcutaneous) GHK-Cu injection is explored in research settings for systemic administration

Schizophr Bull 39 : 130140