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In the original studies included in this review, experiments using longer single sessions (e.g., 60 min of walking or power cycling) often reported smaller or statistically non-significant cognitive effects, whereas experiments using moderate-duration exercise of 3040 min yielded better outcomes

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On the other hand, VEGF-mediated cell invasion is promoted by the expression of MT (membrane type)-MMP (matrix metalloproteinase), MMP-2, MMP-9 and urokinase plasminogen activator which degrade the basal membrane and extracellular matrix allowing migration of endothelial cells and the formation of capillary sprouts [123, 125]

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