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On the contrary, physiological or homeostatic level of ROS is involved in the activation of intracellular pathways responsible for spermatozoa maturation, capacitation, hyperactivation, acrosomal reaction, chemotactic processes, formation of the mitochondrial capsule and condensation of sperm DNA as well as fusion with the female gamete to ensure fertilization

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As individuals age, NAD+ levels naturally decline, which has led to interest in supplementation with NAD+ precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)