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Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ

On one hand, neutrophils significantly contribute to immune dysregulation and tissue damage through the formation of neutrophil extracellular traps (NETs), which are rich in decondensed nucleic acids and expel chromatin that can trigger specific autoreactive immune responses to nucleic acid antigens (79, 80)

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Pineal-derived melatonin and de novo synthesis in the GI tract both produce melatonin which helps regulate gut immunity and intestinal barrier integrity