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We defined S to be a factor multiplying the V max values of GCL and GPX representing the activation of GCL and GPX, so S = 1 for males and S = 1.8 for females for average estradiol, since we make a case based on experimental and clinical results that the activation is by 80%

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Such an imbalance can be the result of several factors: stress-induced over-production of free radicals, a lack of exogenous antioxidants in the diet, a failure of internal defence systems, or increased exposure to reactive species (through smoking, alcohol, pollution ) If it persists, oxidative stress can dramatically affect the bodys principal constituents cells, fatty acids, proteins (such as DNA), sugars contributing to the development of chronic health problems (1-2)