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The immune system hypothesis includes the alteration of the proper functioning of the central nervous system (CNS) associated with an abnormal response to common antigens, stimulation of the inflammatory and cell-mediated immune responses, and upstream regulation of oxidative and nitrosative pathways, and autoimmune responses against neuronal and other cells (Marshall-Gradisnik et al

Common side effects include nausea, vomiting, constipation, and abdominal discomfort, especially during dose escalation

doi: 10.3390/ijms21155262 173 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al