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Because large studies did not show robust, reproducible weightloss outcomes, development as a formal obesity drug was discontinued, and AOD9604 today is typically used offlabel as a wellness or bodycomposition adjunct rather than an FDAapproved obesity medication

In contrast to Ru(II)-OH or NP2, the nanoparticle formulation NP4 has a carbon fluorinated moiety in the polymeric backbone, which could be used for the transport of O 2 and therefore explain this phenomenon