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Cyclic disulfide bond: Enhances molecular stability and prolongs half-life

the BDNF paradox (SSRIs generally raise BDNF and hippocampal neurogenesis via 5-HT1A/5-HT4 signalling, so antidepressant fog is not a synapse-deficiency a peptide refills)

While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

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