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study, CNS malignant melanoma is more likely to be primary if one or more of the following factors are present: a single intracranial lesion, a lesion with intramedullary or leptomeningeal involvement, a pituitary or pineal lesion, a lesion with hydrocephalus, and/or a lesion without malignant melanoma outside the CNS [19]

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The downstream pathway of Nrf2, on the other hand, involves inhibitory effects on oxidative stress, inflammation and apoptosis, including but not limited to several important protein molecules, such as HO-1, SOD, MDA, TNF-, ILs, the caspase family of proteins, Bcl-2 and Bax

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