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Rats with acute pancreatitis had a 21% reduction in cardiac output, a 37% decrease in contractility, a 23% decline in diastolic tension, and a twofold increase in the cardiac tissue edema index [80]

GLP-1R agonism has direct cell autonomous anti-apoptotic effects in the rodent heart, and GLP-1 reduces hypoxia-induced apoptosis in isolated neonatal rat cardiomyocytes, and inhibition of PI3K using LY29400 or MAPK using UO126 blocks the anti-apoptotic effect of GLP-1 [615]

All patients were titrated up to a maximum tolerated dose of 9mg or 12mg including placebo patients