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Here are some of the major triggers of eczematic reactions: Chemical Irritants Chemical irritants can often lead to inflammation and eczematic reactions

Pathogen-associated molecular patterns, such as lipopolysaccharide (LPS), bacterial or viral DNA, and some cytokines (i.e., IFN), induce polarization toward pro-inflammatory (M1-like) macrophages via STAT1, NF-B, and IFN regulatory factor transcription factor signaling, resulting in augmented pro-inflammatory cytokine production (e.g., IL6, IL1, IL8, IL33, TNF-, and IFN-1) [105,106,107]

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Collins et al