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Single Research Group Dominance: The vast majority of published studies originate from a single research group at the University of Zagreb, Croatia, and the lack of independent replication from other laboratories is a noted limitation across the scientific community

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There are many recognized neurological diseases, like epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), stroke, autosomal recessive cerebellar ataxia 2 (ARCA2), Leber's hereditary optic neuropathy (LHON), and spinocerebellar ataxia autosomal recessive 9 (SCAR9)