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The gene mutation causes low levels of C1 INH (HAE type 1) or normal levels of ineffective C1 INH (HAE type 2)

GLP-1 Ozempic/Mounjaro 22.7% CagriSema (REDEFINE-1, 68 ) incretin- 10.8% 26 (Phase 2, Lancet 2021) 2 : 15.6% , 2.2% HbA1c semaglutide ( ) 16 , half-life ~7 - 2 ( REDEFINE-2) / GLP-1 GLP-1 (Ozempic/Mounjaro) cagrilintide +610% , GLP-1 + cagrilintide 2 semaglutide- / advanced users, CagriSema- () , GLP-1 16 (Novo Nordisk Phase 3 CagriSema): 14: 0.25 / 1 /

These facilities are restricted from producing copies of the drugs when the shortage is resolved, though the FDA allows a grace period to fulfill existing in-house orders