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TB500 is used primarily for its healing and regenerative properties

Remarkably, immune checkpoint inhibitor (ICI) treatment targeting the PD-1/PD-L1 pathway is highly effective for metastatic mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) CRC 6

In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems

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