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From a cardiovascular perspective, some GLP-1 receptor agonists (such as liraglutide, semaglutide and dulaglutide) have demonstrated favourable effects in large-scale trials, including reductions in major adverse cardiovascular events (MACE) in patients with established cardiovascular disease

unveils the unique locations of these isoforms, with SLC2A9-L situated on the basolateral membrane of the proximal tubule and SLC2A9-S on the apical membrane of the collecting duct [67]

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