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1 Introduction Chronic constipation (CC) is classified among the disorders of gutbrain interaction (DGBIs), a group of functional gastrointestinal (GI) conditions in which altered communication between the enteric and central nervous systems contributes to symptom generation ( Clinically, CC is defined by persistently difficult or infrequent defecation, excessive straining, hard or lumpy stools, and a sensation of incomplete evacuation
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