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The methylation cycle stalls, and folate becomes trapped in an unusable statea phenomenon clinically referred to as the "folate trap." Because the body can no longer produce adequate amounts of SAMe, the synthesis of crucial neurotransmitters drops dramatically

In chronic conditions like diabetes and obesity, where standard dosing may not be effective for all patients, off-label prescribing is common

For more information, you can contact the Breastfeeding Network Drugs in Breastmilk team

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