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As a synthetic GLP-1 analog sharing approximately 94% sequence homology with native human GLP-1, semaglutide retains the biological activity of the endogenous hormone while incorporating structural modifications that enhance resistance to enzymatic degradation and prolong systemic exposure [2]

Wegovy may still provide metabolic benefits and appetite regulation even during corticosteroid therapy, and weight loss typically improves once the prednisolone course is completed

Clinical trials of semaglutide for weight loss have included patients with various comorbidities, and thyroid disease was not identified as a contraindication or cause for treatment failure

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