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The article describes tirzepatide as acting on both the GLP-1 receptor and the GIP receptor, which its table calls dual-pathway activation, in contrast to semaglutide's single GLP-1 receptor mechanism

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J Alzheimers Dis 59:537541 Shukla D, Mandal PK, Ersland L, Gruner ER, Tripathi M, Raghunathan P, Sharma A, Chaithya GR, Punjabi K, Splaine C (2018) A Multi-center study on human brain glutathione conformation using magnetic resonance spectroscopy

These findings have led to greater interest in understanding the underlying mechanisms of targeting the GIP receptor