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separately, one observational CSF study measured DSIP in 15 men with schizophrenia rather than administering it

In the landmark Phase 3 VESALIUS-CV trial (12,000+ patients), adding Repatha to standard cholesterol-lowering therapy significantly reduced the risk of: Heart attacks Ischemic strokes Coronary deaths This makes Repatha the first PCSK9 inhibitor to demonstrate preventive benefits before heart disease strikes a true paradigm shift in cardiovascular care

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The FDA-approved labeling for exenatide notes that co-administration increased INR in some post-marketing reports, though a dedicated pharmacokinetic study showed no change in warfarin AUC [9]