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8A), indicating that due to the incorporation of the targeting phospholipid CKAAKN-NH-PEG 2000 -DSPE, the ORI@CPD-Lipo (DiR-labeled) has a certain degree of targeting and long-circulating function, and has a certain degree of tumor selectivity in addition to the EPR effect

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Thus, in the setting of IGF-IR resistance in the pituitary and hypothalamus of acromegaly patients, the negative feedback loop by IGF-I may be defective resulting in further IGF-I elevations