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Phase II trial shows that higher doses of up to 16 mg of the GLP-1 receptor agonist (RA) semaglutide improve glycaemia and induce weight loss at the cost of reduced tolerability

Peptide hormones work by binding to specific receptors on the surface of target cells, initiating a cascade of intracellular events that result in the desired biological effect

To minimize discomfort: let the pen sit at room temperature for 30 minutes before injecting, ensure the alcohol on your skin is fully dry, and relax the muscle at the injection site

The study also makes clear that semaglutides benefits are dose-dependent, something that is still being investigated for newer oral drugs