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Future directions may include the incorporation of SIK-inhibitor compounds with traditional UV-blocking sunscreens to minimize UV-related DNA damage in the short term while providing longer term protection through endogenous melanin production

Also, some researchers suggested that Ingenol Mebutate (IM) is a modulator of eight PKC (Protein Kinase C isoenzyme) which involved in the signaling pathways including cell angiogenesis, cell invasion, cell survival/ cell death (survival/autophagy), cell proliferation and acts as either tumor suppressor or oncogenes

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