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Repeated IM injections are painful and inconvenient, and other local side effects such as tissue irritation or fibrosis at injection sites are also concerns, leading to low long-term patient compliance ( 4.4 Intrathecal administration Intrathecal (IT) delivery involves administering the chelator directly into the CSF (often via lumbar puncture or an implanted reservoir), thereby bypassing the BBB ( Molecules administered by intrathecal administration still encounter barriers within the subarachnoid space for drug penetration from CSF into brain parenchyma, but IT dosing creates a favorable concentration gradient for drugs to diffuse

In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development (Strycharz-Dudziak et al., 2020), obesity ( Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

al., 2025 In addition, choline contributes to the synthesis of acetylcholine, an important neurotransmitter involved in nerve signaling

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