In compliance, podocytes-specific deletion of INSR in mice revealed DKD features based on substantial albuminuria and histological features as podocyte foot structure loss and glomerulosclerosis (Welsh et al., 2010)
Water, Glycerin, Stearic Acid, Centella Asiatica Extract (8.4%), Lauric Acid, Potassium Hydroxide, Myristic Acid, 1,2-Hexanediol, Glycol Distearate, Coco-glucoside, Potassium Cocoyl Glycinate, Sorbitan Olivate, Glutathione (1,000ppm), Beeswax, Niacinamide (1,000ppm), Glyceryl Stearate, PEG-100 Stearate, Polysorbate 60, Nelumbo Nucifera Extract, Artemisia Annua Extract, Oryza Sativa (Rice) Extract, Saccharomyces Ferment, Butylene Glycol, Solanum Melongena (Eggplant) Fruit Extract, Melaleuca Alternifolia (Tea Tree) Leaf Extract, Hydrolyzed Collagen, Beta-Glucan, Hippophae Rhamnoides Fruit Extract, Dipropylene Glycol, Hydroxypropyl Methylcellulose, Madecassic Acid, Asiaticoside, Asiatic Acid, Squalane, Sodium Hyaluronate, Disodium EDTA, Caprylic/Capric Triglyceride, Hydrogenated Lecithin, Cholesterol, Xanthan Gum
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This phenomenon may be the result of its unbalanced dual agonistic effect, favoring GIPR over GLP-1R activity [7], because dose escalation of selective GLP-1R agonists induces undesirable gastrointestinal effects
