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It interacts with receptors involved in stress response, circadian regulation, and sleep-wake cycling

Several compounds are under clinical or preclinical investigation for the treatment of tinnitus, including KCNQ potassium channel openers that aim to reduce hyperexcitability in the auditory brainstem, a Group II mGluR agonist to reduce hyperexcitability in the inferior colliculus, NMDAR channel antagonists to reduce excitotoxicity in the cochlea after noise exposure, a glutathione peroxidase (GPx) inhibitor, and a T-type calcium channel blocker to reduce inflammation after noise exposure and in subsequent tinnitus

DOI: 10.1038/s41598-022-05323-7 [Google Scholar] Que Q, Guo X, Zhan L, Chen S, Zhang Z, Ni X, et al

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